When raising children, there are many cases where antibiotics that need to be refrigerated are forgotten and left at room temperature.
Antibiotic Syrup If you can't keep it in the refrigerator, how to deal with it??
Is is OK to keep refrigerated antibiotics at room temperature?
- Refrigerated antibiotics can be degraded if left at room temperature.
- According to the study, about 90% of the drug concentration was maintained up to 5 days at room temperature.**
- Don't panic if you left it outside for a while, open the refrigerator and store your medicine immediately!
- Discard medicines that have been left at room temperature for more than 5 days.
Why must antibiotics syrup be refrigerated?
Actually, not all antibiotics need to be refregerated. However, the combination of amoxicillin + clavulanic acid, which is one of the most widely used antibiotics for infants and children, must be refrigerated. (Representatively, Augmentin Duo)
Because they are very sensitive to heat. Just think of it as Ice cream.
Studies* have shown that as the storage temperature for both amoxicillin and clavulanic acid increases⬆, the time to maintain initial concentration drops⬇ drastically.
What if the concentration of the drug decreases? The antibacterial function, which is the original role of antibiotics, will be somewhat weakened, right? Of course, it won't disappear at all.
However, it would be difficult for a student who attended the party the day before the midterm to get an A+ on the next day's exam.
*Stability of Amoxicillin and Clavulanic Acid in Separate Containers for Administration via a Y-Site Sarah Fawaz et al 2021
Amoxicillin maintained 90% of its initial concentration for 80.3 hours at 4°C, 24.8 hours at 25°C, and 9 hours at 37°C. Clavulanic acid maintained 90% of its initial concentration for 152 hours at 4°C, 26 hours at 25°C, and 6.4 hours at 37°C.
Can I feed amoxicillin + clavulanic acid stored at room temperature my child?
You may be wondering if you can feed antibiotics that need to be refrigerated when left at room temperature. In fact, I don't think there is any clear FDA guidance on this issue.
But, I just summarize my thoughts based on what has been revealed through some researches.
- Amoxicillin + clavulanic acid left at room temperature maintained a concentration of about 90% up to 5 days.**
- Don't be discouraged if you leave it out for a night or so, put it in the fridge right away!
- Even in the hot summer, if you put medicine in an air-conditioned place, feed the medicine.
- Discard amoxicillin + clavulanic acid that has been left in a hot place for more than 5 days!
** Stability of reconstituted amoxicillin clavulanate potassium under simulated in-home storage conditions Nwokoye Peace, Oyetunde Olubukola and Akinleye Moshood 2012
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